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Wednesday
After nighttime treatment, clinical recovery was significantly enhanced and the mean number of side effects was significantly lower. -- Journal of Neurology, Neurosurgery, and Psychiatry
Background: The activity of the immune system displays a circadian rhythm. In diseases characterized by aberrant immune activity, chronotherapy - treatment regimen tailored to diurnal body rhythms - may increase medication efficiency, safety, and tolerability.
The goal of this study was to compare the outcomes of intravenous corticosteroid administration during the day or night, for treatment of acute multiple sclerosis (MS) relapses.
Methods: Seventeen MS patients were included in the study. Clinical assessment of disability was performed at trial entry, and at days 7 and 30 from therapy initiation. Adverse events and preference of nighttime versus daytime therapy were assessed at the end of the treatment course.
Results: After nighttime treatment, clinical recovery was significantly enhanced and the mean number of side effects was significantly lower. Furthermore, the majority of patients expressed a preference for nighttime versus daytime treatment.....
CLICK FOR MORE OF THIS ABSTRACT
Background: The activity of the immune system displays a circadian rhythm. In diseases characterized by aberrant immune activity, chronotherapy - treatment regimen tailored to diurnal body rhythms - may increase medication efficiency, safety, and tolerability.
The goal of this study was to compare the outcomes of intravenous corticosteroid administration during the day or night, for treatment of acute multiple sclerosis (MS) relapses.
Methods: Seventeen MS patients were included in the study. Clinical assessment of disability was performed at trial entry, and at days 7 and 30 from therapy initiation. Adverse events and preference of nighttime versus daytime therapy were assessed at the end of the treatment course.
Results: After nighttime treatment, clinical recovery was significantly enhanced and the mean number of side effects was significantly lower. Furthermore, the majority of patients expressed a preference for nighttime versus daytime treatment.....
CLICK FOR MORE OF THIS ABSTRACT